A STUDY OF HUMORAL AND CELL-MEDIATED IMMUNE-RESPONSE FOLLOWING TYPHOID VACCINATION IN HUMAN VOLUNTEERS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 47  (2) , 275-282
Abstract
The specific antibody response to O, H and Vi antigens, the levels of IgG, IgM, IgA and complement component C3, the presence of soluble immune complexes, the in vitro tests of cellular immunity, and the subsets of lymphocytes in the peripheral blood were investigated in human volunteers after a single dose of 0.1 ml intradermal typhoid vaccination. Typhoid vaccination induced antibody formation, slightly increased IgA levels and led to a decrease in C3 which was probably due to immune complex formation. There was also a relative increase in circulating Fc-IgG receptor-bearing lymphocytes and T-.gamma. cells after vaccination. In those subjects who showed specific cellular immunity before vaccination, a transient depression in lymphocyte transformation and a negative leukocyte migration inhibition test with typhoid baccilli occurred post-vaccination. These findings raise doubts over the advantages of giving typhoid vaccine during an epidemic.