Ruthenium-Catalyzed C−H/CO/Olefin Coupling Reaction of N-Arylpyrazoles. Extraordinary Reactivity of N-Arylpyrazoles toward Carbonylation at C−H Bonds
- 26 August 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 68 (19) , 7538-7540
- https://doi.org/10.1021/jo0343127
Abstract
The reaction of 1-arylpyrazoles with CO and ethylene in the presence of Ru(3)(CO)(12) resulted in regioselective carbonylation at the ortho C-H bonds. While it is found that the pyrazole ring also functions as the directing group for C-H bond cleavage, the efficiency of the reaction depends on the position of the pyrazole ring.Keywords
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