Benzodiazepine Receptor: Demonstration in the Central Nervous System
- 25 November 1977
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 198 (4319) , 849-851
- https://doi.org/10.1126/science.918669
Abstract
Diazepam, a potent minor tranquilizer, binds with high affinity to a specific benzodiazepine receptor that occurs exclusively in the central nervous system. The receptor is mainly localized in the synaptic membrane fraction. Binding to the receptor is stereospecific. Competition for the receptor by various benzodiazepines closely parallels their pharmacological potency.Keywords
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