EXTRANEURAL GROWTH OF POLIOMYELITIS VIRUS
- 2 August 1947
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 134 (14) , 1154-1155
- https://doi.org/10.1001/jama.1947.02880310012003
Abstract
Attempts to demonstrate the growth of poliomyelitis virus in cells other than neurons have repeatedly failed1(1936). As a result the opinion has been prevalent that in the human body growth of the virus is limited to nerve cells. That this conclusion is premature and may well be wrong is indicated by a number of well established facts relative to (1) the amount of poliomyelitis virus in human feces; (2) the prolonged period of excretion of virus in feces; (3) the usually short period of growth of virus in the central nervous system of experimental animals, and (4) the frequent intestinal infection without apparent neurologic infection seen in work with Theiler's virus in mice. The information available in regard to the amounts of poliomyelitis virus in feces casts considerable doubt on the idea that this virus grows only in nerve tissue. In tests with pooled fecal specimens from 25Keywords
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