Effect of Dose Distribution on the Induction of Experimental Lung Cancer by Alpha Radiation

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Abstract
The relative carcinogenicity of 210Po administered intratracheally in Syrian hamsters by 2 different methods was studied. In the 1st, 210Po was instilled in soluble form in a saline solution yielding a uniform distribution of radioactivity throughout the lung parenchyma. In the 2nd, 210Po was administered adsorbed onto Fe2O3 carrier particles that yielded a highly non-uniform distribution of radiation dose. With lifetime doses averaged over the whole lungs of 55-2700 rad, the tumor yields for the non-uniform hot-spot irradiation were equal to or less than those for uniform exposure. The assessment of the hazards of inhaled .alpha. emitters utilizing a model based on uniform distribution apparently is a reasonable approach for radiation protection purposes.

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