Flavonoids and Stilbenoids with COX-1 and COX-2 Inhibitory Activity fromDracaena loureiri
- 30 September 2002
- journal article
- letter
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 68 (9) , 841-843
- https://doi.org/10.1055/s-2002-34403
Abstract
Fom the stem wood of Dracaena loureiri, a new homoisoflavanone named loureiriol (1) and eight known flavonoid and stilbenoid derivatives, including 5,7-dihydroxy-3-(4-hydroxybenzyl)-4-chromanone (2), 4,4′-dihydroxy-2,6-dimethoxydihydrochalcone (3), 2,4′-dihydroxy-4,6-dimethoxydihydrochalcone (4), 4′-hydroxy-2,4,6-trimethoxydihydrochalcone (5), 4,6,4′-trihydroxy-2-methoxydihydrochalcone (6), 4,3′,5′-trihydroxystilbene (7), 4,3′-dihydroxy-5′-methoxystilbene (8) and 4-hydroxy-3′,5′-dimethoxystilbene (9) were isolated. These compounds were evaluated for their inhibitory activity against the enzymes cyclooxygenase-1 and cyclooxygenase-2. Potent but non-selective activity was found for the stilbenoids 7 - 9 (IC50 1.29 - 4.92 μM) whereas weak or no activity was observed for the flavonoids 1 - 6.Keywords
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