Alpha-2 Adrenergic Receptor Agonists for the Treatment of Attention-Deficit/Hyperactivity Disorder: Emerging Concepts from New Data
- 1 August 2007
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Child and Adolescent Psychopharmacology
- Vol. 17 (4) , 393-406
- https://doi.org/10.1089/cap.2006.0098
Abstract
Recent developments in the field of neuroscience have illuminated the understanding of the neural circuits impaired in attention-deficit/hyperactivity disorder (ADHD) and the mechanism of action of treatments used to treat this condition. There is an exciting confluence between emerging studies in basic neurobiology and the genetic, neuroimaging, and neuropsychological analyses of ADHD. The following provides a brief review of this field, explaining how compounds like guanfacine and the traditional stimulant medications can reduce the core symptoms of ADHD by optimizing the neurochemical environment in the prefrontal cortex (PFC). Knowledge of these basic mechanisms may inform our medication choices and facilitate treatment of ADHD and related disorders.Keywords
This publication has 114 references indexed in Scilit:
- Protein kinase A as a therapeutic target for memory disorders: rationale and challengesTrends in Molecular Medicine, 2005
- Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controlsMolecular Psychiatry, 2005
- Orbitofrontal cortex dysfunction in attention-deficit hyperactivity disorder revealed by reversal and extinction tasksNeuroReport, 2002
- Developmental Instability and Working Memory Ability in Children: A Magnetic Resonance Spectroscopy InvestigationDevelopmental Neuropsychology, 2000
- A Pilot Study of Methyiphenidate, Clonidine, or the Combination in ADHD Comorbid with Aggressive Oppositional Defiant or Conduct DisorderClinical Pediatrics, 2000
- Delayed-response deficit induced by local injection of the α2-adrenergic antagonist yohimbine into the dorsolateral prefrontal cortex in young adult monkeysBehavioral and Neural Biology, 1994
- Reserpine impairs spatial working memory performance in monkeys: reversal by the α2-adrenergic agonist clonidineBrain Research, 1993
- The C1 area of the brainstem in tonic and reflex control of blood pressure. State of the art lecture.Hypertension, 1988
- GuanfacineDrugs, 1986
- Comparison of guanfacine versus clonidine for efficacy, safety and occurrence of withdrawal syndrome in step-2 treatment of mild to moderate essential hypertensionThe American Journal of Cardiology, 1986