Effects of Dietary Fat upon Plasma Polyunsaturated Acids.

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Abstract
The content of polyunsaturated acids in human plasma was measured by alkaline isomerization. Humans were fed controlled diets containing different dietary fats. When the dietary fat was corn oil, the diene content of the plasma lipids was high and the ratio of trienoic acids to tetraenoic acids was low. When the diet contained saturated fat, the reverse was true. It appears that the intake of large amounts of saturated fats gives changes in polyunsaturated acids similar to those seen in essential fatty acid deficiency. In 1 case of familial hypercholesterolemia, ethyl linoleate feeding caused changes in plasma lipids similar to those found when corn oil was fed.

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