Fertility regulating and immunotherapeutic vaccines reaching human trials stage
Open Access
- 1 July 1997
- journal article
- review article
- Published by Oxford University Press (OUP) in Human Reproduction Update
- Vol. 3 (4) , 301-310
- https://doi.org/10.1093/humupd/3.4.301
Abstract
The progress and current status of vaccines which induce antibodies against human chorionic gonadotrophin (HCG) and luteinizing hormone-releasing hormone (LHRH) are reviewed. Three vaccines devised against HCG have undergone phase I clinical trials documenting their safety, and reversibility. One of these, the heterospecies dimer (HSD)-HCG vaccine has also completed phase II efficacy trials in sexually active women of proven fertility. Immunization with the vaccine prevents pregnancy, as long as the antibody titres remain ≥50 ng/ml HCG bioneutralization capacity. There is no disturbance of menstrual regularity and women continue to ovulate normally. The antibody response is predominantly against an epitope in the core part of β-HCG. Fertility is regained at titres Keywords: fertility control/HCG/human trials/immunization/LHRHKeywords
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