Hypocholesterolemic activities of LK-903 and clofibrate in miniature pigs, cynomolgus monkeys and beagle dogs.

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Abstract
The hypocholesterolemic activities of LK-903 (α-methyl-p-myristyloxycinnamic acid-1-monoglyceride) and clofibrate were examined in miniature pigs (OHMINI-875) and beagle dogs. When administered in the diet for one week, LK-903 and clofibrate were active in the miniature pig at doses of 5 and 10 mg/kg/day, respectively, whereas the two drugs showed no hypocholesterolemic activity in the beagle dog. In cynomolgus monkeys, LK-903 showed a hypocholesterolemic effect, but serum cholesterol depression was less marked than in the miniature pig.

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