XANTHOGRANULOMATOUS CHOLECYSTITIS - CASE-REPORT AND REVIEW OF THE LITERATURE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 106  (6) , 302-304
Abstract
A case of xanthogranulomatous cholecystitis, an entity rarely described in the English-language literature, is described. This lesion was unique with regard to the extent of involvement. It was grossly characterized by a markedly thickened gallbladder wall that was yellowish and granular. Microscopically, the gallbaladder was diffusely infiltrated by foamy macrophages that contained lipofuscin, lipid material and bile pigment, features corroborated by transmission electron microscopy. The origin and pathogenesis of xanthogranulomatous cholecystitis were reviewed. In the presence of obstruction and bile stasis, the combination of inflammation, tissue necrosis and bile extravasation will lead to the formation of xanthogranulomas similar to that produced in experimental pyelonephritis.

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