Effect of glutamine on the degradation of glutamine synthetase in hepatoma tissue-culture cells

Publisher Website
Google Scholar
Abstract
In certain lines of [rat] hepatoma tissue culture cells, the extracellular glutamine concentration regulates the specific activity of glutamine synthetase. By quantifying the radioactivity in immunoprecipitated glutamine synthetase on polyacrylamide gels, the rate of degradation, but not of synthesis, of glutamine synthetase was found to be a sensitive function of extracellular glutamine. The activity that degrades this enzyme appears to be labile.