Cellular Warriors at the Battle of the Bulge

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Abstract
The tools of molecular genetics have yielded a rush of new information about molecular signals that regulate body weight. Some guide short-term decisions, such as whether to eat now or push away from the table. Other molecules take a longer view, monitoring fat balance. One message coming out of this work is depressing for people who want to lose weight: The body9s weight-control systems have apparently been designed to protect more against weight loss than weight gain.

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