STREPTOZOTOCIN-INDUCED DIABETES IN RAT .2. LIPID AND LIPID PEROXIDE CHANGES OF LIPOPROTEIN FRACTIONS IN DIABETES COMPLICATED BY HYPERTENSION AND MYOCARDIAL-INFARCTION

  • 1 December 1988
    • journal article
    • research article
    • Vol. 10  (12) , 751-754
Abstract
Lipid peroxide levels and plasma lipids were studied in plasma lipoprotein fractions of streptozotocin diabetic rats, spontaneous hypertensive rats (SHR) + diabetes, and in myocardial infarction rats (MIR) + diabetes. The duration of diabetes in all experimental group was 2.5 months. We found a tendency of elevation of cholesterol in VLDL and fall in HDL2 but the differences were not significant. Total plasma triglycerides were increased in the three diabetic groups, and the increase was due to LDL fraction but again the differences were not significant. The lipid peroxide (LP) level in total plasma showed a significnt increase in the three diabetic groups: in Wistar diabetic rats LP increased 3 times, in MIR + diabetes 3.5 times, and in SHR + diabetes 5 times. The increase of LP in the three diabetic groups was due to LDL with good correlation (r = 0.60) between LP and triglycerides in LDL of the three diabetic groups. The results are in agreement with concept of the importance of lipoprotein fraction changes: increased cholesterol, triglycerides and lipid peroxides in atherozenic (VLDL and LDL) fractions, and decreased levels in antiatherogenic (HDL, HDL2) fractions in diabetes mellitus.