Paternal History of Coronary-Heart Disease Reported by Marathon Runners

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Abstract
MOST prospective and retrospective epidemiologic studies show an inverse relation between physical activity and coronary-heart disease.1 2 3 4 In the most recently reported prospective study of Harvard alumni, in which leisure activity was assessed by questionnaire, there was a strong relation between decreased risk of coronary-heart disease and increased exercise levels.1 None of these studies resolves, however, the issue of selection versus protection. In other words, it is not known whether those who exercise regularly make up a self-selected group in which the risk of coronary disease is reduced, or whether regular exercise itself exerts a protective effect against this disease.Direct . . .