Isoproterenol Stimulation of Heme Synthesis in Cultures of Human Fetal Liver from Early Gestation

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Abstract
The role of isoproterenol in the synthesis of heme associated with Hb was studied in primary cultures of human fetal liver. This drug (10-10 M) stimulated the incorporation of 59Fe into heme associated with Hb in cell cultures of livers obtained from human fetuses 8-10 wk gestation but was inactive in cell cultures prepared from livers of older fetuses. Isoproterenol had its optimal activity at a much earlier time in gestation than that previously reported for testosterone or erythropoietin. There was present a cell population in human fetal liver early in gestation with the appropriate isoproterenol-receptors and capable of erythroid differentiation after exposure to the drug.

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