Zincke's Reaction with Chiral Primary Amines: A Practical Entry to Pyridinium Salts of Interest in Asymmetric Synthesis
- 1 January 1992
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1992 (05) , 431-434
- https://doi.org/10.1055/s-1992-21371
Abstract
The scope of Zincke's synthesis of pyridinium salts using various chiral primary amines and mono- or dialkylpyridines substituted at positions 3, 4 or 5 has been investigated. Salts 6a-f, 9a-i, and 10b,e,h-j were obtained in excellent yields. The results support the accepted mechanism for Zincke's reaction and shows the influence of the solvent on the course of this reaction.Keywords
This publication has 0 references indexed in Scilit: