Effect of Diet on Experimental Pancreatitis in Rat

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Abstract
One hundred and seventy-nine Wistar rats were divided into six groups of different diets and were kept on for four to six months and then subjected to ligation of the common bile duct just proximal to its opening to the duodenum. The results obtained were as follows: 1) Except one group of the high carbohydrate diet in which there was no death within three days following the ligation, 50% of the rats died on the second or third day, the highest mortality of 20-66% being found in the group of high protein diet. 2) No significant difference of serum amylase levels was found among the experimental groups. 3) The histologic study of the pancreas disclosed a severe parenchymal necrosis in the groups of high protein diet and high protein and high fat diet, whereas no such change was noted in the groups of high carbohydrate and standard diet. 4) It was assumed that the difference in clinical pictures of pancreatitis between the Japanese and Western peoples might be due to difference in dietary habit.