Electro‐Deprotection—Electrochemical Removal of Protecting Groups
- 1 May 1976
- journal article
- review article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 15 (5) , 281-292
- https://doi.org/10.1002/anie.197602811
Abstract
The reactions of electrochemical splitting may be successfully used for removal of protecting groups. Theoretical and preparative aspects of the method of electro‐deprotection are discussed, and examples of its use are given. The removal often requires high potentials. The use of modified protecting groups (“inner activation”) or of catalysts (electron carriers) which facilitate electron transfer against the standard potential gradient (“external activation”), can greatly increase the scope of the electrochemical method.Keywords
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