Early activation of PBMC and appearance of antiviral CD8+ cells influence the prognosis of SIV‐induced disease in rhesus macaques
- 5 February 1994
- journal article
- research article
- Published by Wiley in Journal of Medical Primatology
- Vol. 23 (2-3) , 108-116
- https://doi.org/10.1111/j.1600-0684.1994.tb00110.x
Abstract
We studied 15 macaques inoculated with SIV and identified three phases of infection. Phase 1 was characterized by activated lymphocytes in blood and infected cells in the CSF. In phase 2, activated cells were not detected but virus was recovered from mitogen-stimulated PBMC, while in phase 3, virus was recovered from mitogen-stimulated PBMC only after depletion of CD8+ lymphocytes, indicating effective control of the virus in peripheral blood. Early development of phase 3 status correlated with a longer period of clinical normalcy.Keywords
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