Sites of First-Pass Bioactivation (Hydrolysis) of Orally Administered Zofenopril Calcium in Dogs
- 1 January 1991
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 08 (3) , 370-375
- https://doi.org/10.1023/a:1015853801329
Abstract
The relative contribution of the gut, liver, and lungs as sites of first-pass bioactivation (hydrolysis) of the orally administered ester prodrug, zofenopril calcium (SQ 26,991), to the active...Keywords
This publication has 12 references indexed in Scilit:
- Simultaneous determination of the prodrug zofenopril and its active drug in plasma by capillary gas chromatography-mass-selective detectionJournal of Chromatography B: Biomedical Sciences and Applications, 1988
- QUANTITATION OF EXTRAHEPATIC METABOLISM - PULMONARY AND INTESTINAL CONJUGATION OF NAPHTHOL1985
- Chronic catheterization of the portal vein in dogs.1983
- TOTAL-BODY CLEARANCE OF CIRCULATING BENZO(A)PYRENE IN CONSCIOUS RATS - EFFECT OF PRETREATMENT WITH 3-METHYLCHOLANTHRENE AND THE ROLE OF LIVER AND LUNG1983
- A comparison of numerical integrating algorithms by trapezoidal, Lagrange, and spline approximationJournal of Pharmacokinetics and Biopharmaceutics, 1978
- Effect of portacaval shunt on the disposition of drugs with and without first-pass effect.1975
- Effects of route of administration and blood flow on hepatic drug elimination.The Journal of Pharmacology and Experimental Therapeutics, 1975
- Methotrexate PharmacokineticsJournal of Pharmaceutical Sciences, 1971
- Oral absorption and disposition kinetics of lidocaine hydrochloride in dogs.1970
- Influence of the Route of Administration on the Area Under the Plasma Concentration-Time CurveJournal of Pharmaceutical Sciences, 1969