On the translocation of proteins across membranes.
Open Access
- 1 February 1987
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 84 (4) , 1015-1019
- https://doi.org/10.1073/pnas.84.4.1015
Abstract
Many proteins of intracellular organelles are first synthesized in the cytoplasm and are then specifically transferred across the membranes of the organelles. On the assumption that these transfers all occur by the same basic mechanism, we enumerate the rather stringent requirements that the mechanism, must satisfy. A unitary molecular mechanism is then proposed that meets these requirements.This publication has 55 references indexed in Scilit:
- Uncoupling Translocation from Translation: Implications for Transport of Proteins Across MembranesScience, 1986
- The amino terminus of the yeast F1-ATPase beta-subunit precursor functions as a mitochondrial import signal.The Journal of cell biology, 1986
- Dual functions of the signal peptide in protein transfer across the membraneCell, 1985
- Translocation of secretory proteins across the microsomal membrane occurs through an environment accessible to aqueous perturbantsCell, 1985
- Signal sequencesJournal of Molecular Biology, 1985
- In Vivo Function and Membrane Binding Properties Are Correlated for Escherichia coli lamB Signal PeptidesScience, 1985
- Exploring the conformational roles of signal sequences: synthesis and conformational analysis of .lambda. receptor protein wild-type and mutant signal peptidesBiochemistry, 1984
- How mitochondria import proteinsBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1984
- Trans‐membrane Translocation of ProteinsEuropean Journal of Biochemistry, 1979
- The Croonian Lecture, 1968 - The haemoglobin moleculeProceedings of the Royal Society of London. B. Biological Sciences, 1969