Protein Composition and Growth-Promoting Activity of the Serum after Whole-Body X-Irradiation at Different Ages
- 1 June 1963
- journal article
- research article
- Published by JSTOR in Radiation Research
- Vol. 19 (2) , 286-+
- https://doi.org/10.2307/3571450
Abstract
In contrast to previous reports on the inhibition of the growth of cell cultures with serum from irradiated rabbits, no such effect could be demonstrated with serum from irradiated rats. Electrophoretic analysis of the serum proteins showed that in rabbits the [beta]-lipoproteins increased promptly after irradiation, in rats this increase concerned the a2-glycoproteins. Since only the former fraction is known to be toxic for cells in culture, it is concluded that the different effects of the two sera on cell cultures are related to differences in the composition of the proteins of the sera following irradiation and not to the presence of any specific radiotoxins.Keywords
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