Studies on fungal products. IX Dethiosecoemestrin, a new metabolite related to emestrin, from Emericella striata.
- 1 January 1986
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 34 (6) , 2411-2416
- https://doi.org/10.1248/cpb.34.2411
Abstract
In the course of searching for metabolites related to emestrin (3) from Emericella striata (80-NE-22), dethiosecoemestrin (1) was isolated from the methylene chloride extract of the culture filtrate. The tremorgenic mycotoxin, paxilline (6), was also isolated from the mycelial extract. The structure of dethiosecoemestrin was established on the basis of the chemical and spectroscopic evidence as 1. It is postulated that dethiosecoemestrin was biogenetically derived from emestrin. Dethiosecoemestrin was easily degraded to violaceic acid (5). The antimicrobial activity of dethiosecoemestrin was examined.This publication has 2 references indexed in Scilit:
- Studies on fungal products. Part 8. Isolation and structure of emestrin, a novel antifungal macrocyclic epidithiodioxopiperazine from Emericella striata. X-Ray molecular structure of emestrinJournal of the Chemical Society, Perkin Transactions 1, 1986
- Une nouvelle methode de synthese peptidique intramoleculaire, applicable a la sarcosine, a l'aide de derives de l'aide oxaliqueTetrahedron, 1984