CYTOPATHOLOGIC CHARACTERISTICS OF PERMANENT CELL-LINES DERIVED FROM ANAPLASTIC HUMAN GLIOMAS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 23  (5) , 412-419
Abstract
Permanent cell lines [U-138 MG, U-373 MG, U-410 MG, D-54 MG and D-37 MG] derived from human gliomas were examined at 24 h intervals to determine optimal phases of their population growth curves for comparative morphologic studies. In early exponential growth phase, individual cytologic criteria were displayed, while the increased cellular density of late exponential and plateau phase growth was advantageous for evaluating growth pattern, bizare multinucleate giant cells and abnormal mitoses. These morphologic characteristics of permanent cell lines derived from human gliomas are potentially useful for correlation with their biologic, immunologic, biochemical and cell biologic parameters.