Interaction of antidepressants with clonidine on rat brain total 3-methoxy-4-hydroxyphenylglycol
- 1 April 1979
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 57 (4) , 435-437
- https://doi.org/10.1139/y79-067
Abstract
The effects of some antidepressants on brain total 3-methoxy-4-hydroxyphenylglycol (MHPG) were studied in the rat. Desipramine decreased and mianserine increased the brain total MHPG concentration while the other antidepressants had no effect. They were also the only antidepressants that attenuated the lowering action of clonidine on brain total MHPG, but possibly through different mechanisms. Two tertiary amine tricyclic antidepressants, amitriptyline and imipramine, appeared to enhance the lowering action of clonidine on brain total MHPG. The results suggest that antidepressants are heterogeneous in their actions on brain noradrenergic mechanisms in the rat.This publication has 3 references indexed in Scilit:
- Presynaptic Alpha-Receptor Subsensitivity After Long-Term Antidepressant TreatmentScience, 1978
- Blockade of presynaptic ?-receptors and of amine uptake in the rat brain by the antidepressant mianserineNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1977
- Subsensitivity of presynaptic α-adrenoceptors after exposure to noradrenalineEuropean Journal of Pharmacology, 1977