Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go.
- 1 September 1990
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 87 (17) , 6477-6481
- https://doi.org/10.1073/pnas.87.17.6477
Abstract
The .alpha. subunit of the guanine nucleotide-binding protein Go ("o" for other) is believed to mediate signal transduction between a variety of receptors and effectors. cDNA clones encoding two forms of Go .alpha. subunit were isolated from a mouse brain library. These two forms, which we call GoA.alpha. and GoB.alpha., appear to be the products of alternative splicing. GoA.alpha. differs from GoB.alpha. over the C-terminal third of the deduced protein sequence. Both forms are predicted to be substrates for ADP-ribosylation by pertussis toxin. GoA.alpha. transcripts are present in a variety of tissues but are most abundant in brain. The GoB.alpha. transcript is expressed at highest levels in brain and testis. It is possible that GoA.alpha. and GoB.alpha. have different functions.This publication has 32 references indexed in Scilit:
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