Plasma Theophylline Concentrations Measured by High-Pressure Liquid Chromatography
- 1 November 1975
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 21 (12) , 1774-1776
- https://doi.org/10.1093/clinchem/21.12.1774
Abstract
We present a specific, sensitive high-pressure liquidchromatographic assay for theophylline in plasma. Only 0.5 ml of plasma is required for each determination, and the lower limit of detection by this method is 0.1 mg/ liter. Other xanthines and their metabolites do not interfere. This method is suitable for use in studying the pharmacokinetics of this drug in infants and children, from whom only small volumes of blood are available.Keywords
This publication has 0 references indexed in Scilit: