Scrapie: A Prototype Slow Infection

Publisher Website
Google Scholar
Abstract
The main distinguishing characteristics of the subacute spongiform encephalopathies are outlined; it is suggested that the group of diseases covered by the term “subacute spongiform encephalopathies” should be considered as distinct in their properties from other slow infections. The early experimental work in scrapie is briefly reviewed. Biochemical changes in brain that are characteristic of scrapie are summarized. Recent physicochemical studies of the properties of the scrapie agent are considered in relation to the biological nature of the scrapie agent. The replication of the scrapie agent is discussed in terms of viral and membrane hypotheses of scrapie and in the light of recent genetic studies of mouse scapie.

This publication has 0 references indexed in Scilit: