Antibiotic-Tolerant Staphylococcus aureus

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Abstract
In 1977, Sabath, et al., described a new type of penicillin resistance in strains of Staphylococcus aureus. These strains were inhibited by low concentrations of nafcillin, but high concentrations of this antibiotic were not lethal. The ratio of the minimum bactericidal concentration (MBC) to the minimum inhibitory concentration (MIC) varied from 128 to 2000. The authors designated these strains as “tolerant” and suggested that tolerance is “a common, clinically important form of penicillin resistance, that differs from previously described forms of penicillin resistance, that due to /8-lactamase, and that due to ‘intrinsic’ (e.g., methicillin resistance) mechanisms.” This report examines some of the laboratory and clinical aspects of antibiotic-tolerant S. aureus.

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