Effect of Renal Transplantation on the Levels of Choline in the Plasma of Uremic Humans

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Abstract
Plasma choline levels were measured in patients who received a kidney transplant, in donors who underwent nephrectomy and in nonrenal surgical patients. Choline was measured using a choline kinase assay. Choline levels in patients receiving a kidney fell from 29.8 .+-. 1.86 .mu.M before transplantation to 15.7 .+-. 2.32 one day later; this normal level was maintained for at least 7 mo. and in 1 case for 2 yr. Kidney donors and nonrenal surgery patients showed a significant decrease in plasma choline on the day following surgery but choline levels returned to normal by 3 days after surgery. A transplanted functional kidney reduced high plasma choline levels, associated with uremia, to normal and maintained these levels thorughout the period of observation.

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