Coexistence of α-Thalassemia and a New Pyruvate Kinase Variant: PK Fukien

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Abstract
A 12-yr-old male of Chinese ancestry had life-long hemolytic anemia attributed to .alpha.-thalassemia. Restriction endonuclease mapping of his DNA revealed that, in reality, he had 3 .alpha.-globin loci, but he was homozygous for pyruvate kinase deficiency. The new pyruvate kinase variant carried by this patient was characterized and designated PK Fukien.