Stimulation of Prolactin Secretion by Perphenazine in Pituitary-Hypothalamus Organ Culture.
- 1 November 1963
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 114 (2) , 366-368
- https://doi.org/10.3181/00379727-114-28679
Abstract
Summary Pituitary explants on medium “199′”released an average of 0.05 IU prolactin daily. Pituitary-hypothalamus co-cultures released only an average of 0.025 IU/d. Other brain parts in co-culture failed to depress prolactin release, nor did hypothalami of perphenazine-primed rats or hypothalami to which perphenazine was added in vitro. The method described is a valuable tool for appraisal of prolactin releasing or inhibiting agents.Keywords
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