Microglial Apoptosis Induced by Chromogranin A Is Mediated by Mitochondrial Depolarisation and the Permeability Transition but Not by Cytochrome c Release
Open Access
- 1 April 2000
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 74 (4) , 1452-1462
- https://doi.org/10.1046/j.1471-4159.2000.0741452.x
Abstract
Chromogranin A is up‐regulated in the senile plaques of Alzheimer's brain and is a novel activator of microglia, transforming them to a neurotoxic phenotype. Treatment of primary cultures ...Keywords
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