Oscillations of Granulocytic and Megakaryocytic Progenitor Cell Populations in Cyclic Neutropenia in Man

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Abstract
The concentration of granulocytic progenitor cells in the bone marrow of 2 patients with cyclic neutropenia was assessed at intervals during the cycle. Syncroneous oscillations were observed for cells forming neutrophilic and megakaryocytic colonies in diffusion chambers in viva (CFU‐D), suggesting a close relationship between the two cell types. However, an almost reverse relationship was observed between CFU‐D and cells forming colonies in agar culture1 in vitro (CFU‐C), which cycled out of phase with CFU‐D. This supports the concept that CFU‐D and CFU‐C denote different cell types.