Posttraining intra-basolateral amygdala scopolamine impairs food- and amphetamine-induced conditioned place preferences.
- 1 January 2002
- journal article
- research article
- Published by American Psychological Association (APA) in Behavioral Neuroscience
- Vol. 116 (5) , 922-927
- https://doi.org/10.1037//0735-7044.116.5.922
Abstract
The present study investigated the role of cholinergic muscarinic receptor function within the basolateral amygdala memory in the consolidation of conditioned place preference (CPP) memory. Adult male Long-Evans rats were confined to treatment- or nontreatment-paired compartments for 30 min on 4 alternating days. After training, rats received intrabasolateral amygdala infusions of scopolamine (2.5 microg or 5.0 microg/0.5 microl) or saline. The rats were then given a 20-min test session, and the time spent in each of the compartments was recorded. Immediate posttraining (but not delayed 2 hr) scopolamine (5.0 microg) blocked acquisition of food- and amphetamine-induced CPPs. The findings indicate a time-dependent role for basolateral amygdala muscarinic receptors in memory consolidation underlying CPPs for natural and drug rewards.Keywords
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