SWINE VESICULAR DISEASE VIRUSES ISOLATED FROM HEALTHY PIGS IN NON-EPIZOOTIC PERIOD .2. VESICULAR FORMATION AND VIRUS MULTIPLICATION IN EXPERIMENTALLY INOCULATED PIGS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 20  (4) , 123-130
Abstract
An infection experiment was carried out on pigs with swine vesicular disease virus isolated from healthy pigs (SVDV-H). Inoculation was done by 2 routes; the routes were intradermally into the coronary band of the foot and orally. Observations were made on the formation of vesicles and their spread, virus content of serum swabs of the oral cavity and feces, neutralizing antibody titers and the distribution of virus in the body. In the pigs inoculated intradermally there was a difference in the extension of the area involved in vesicular formation between any 2 strains of virus; vesicular formation was restricted to the site of inoculation, involved the site of inoculation and the sole of the hoof or spread over the oral and nasal regions. In every pig vesicles developed for 2-5 days after inoculation after which, repair progressed rapidly. Some strains caused mild viremia. The virus was detected from the site of vesicular formation but not from any organ. Neutralizing antibody was first detected 3 days after inoculation; the titer reached a plateau .apprx. 10 days later. In the pigs inoculated perorally, no vesicles were formed. The virus was only detected from the tonsils and the intestinal contents. SVDV-H was less pathogenic than swine vesicular disease virus isolated from diseased pigs.

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