Butobarbitone metabolism in man: identification of 3î-ketobutobarbitone

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Abstract
After single 200 mg oral doses of butobarbitone (I) in man, 5·4% was excreted in urine unchanged and 28·2% as the 3î-hydroxy metabolite (II) in six days. A new metabolite, the ketone (III), was detected in urine following oral administration both of I and of II. Oxidation of the hydroxy to the ketone metabolite was demonstrated in vitro with the 9000g fraction of rat liver. Use was made of selective ion monitoring g.c.-m.s. methods in metabolite detection.