Correlation of Cerebral Blood Flow with Outcome in Head Injured Patients

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Abstract
To determine the relationship of cerebral blood flow (CBF) to the clinical outcome of head injury, serial determinations of CBF were performed by the i.v. Xe technique in 24 patients. The patients were of mixed injury severity and were classified into 4 groups depending on the neurological exam at the time of each CBF study. All 8 patients who were lethargic on admission demonstrated increases in their minimally depressed CBF as they improved to normal status. Patients (11) in deep stupor or coma ultimately recovered. Of these patients (10) initially had moderate to profound decreases in CBF which improved as recovery occurred. The single exception was an adolescent whose initial CBF was high but became normal at recovery. Five comatose patients died. In 4 of these, already depressed CBF fell even lower; 1 adolescent with initially increased CBF developed very low CBF preterminally. A good correlation was demonstrated between CBF and clinical outcome. In all of the adult survivors, depressed CBF increased as the patient recovered to normal status. All adults who died showed a deterioration of CBF as the neurological status worsened. The only exceptions were 2 adolescents who initially showed high CBF values. In the adolescent who died, CBF dropped to low levels while in the survivor a normal CBF was achieved. In adults a traumatic brain injury was associated with depressed CBF which increased with recovery or decreased further with deterioration; the reaction to injury was quite different in the younger brain.