Neurochemical Perspectives of the Narcoleptic Syndrome
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in International Journal of Neuroscience
- Vol. 38 (1-2) , 21-30
- https://doi.org/10.3109/00207458809000478
Abstract
Narcolepsy has been defined as a disorder of excessive sleep often associated with cataplexy, sleep paralysis and hypnagogic hallucinations. Although the pathophysiology of the narcoleptic syndrome is not well understood, derangement in the functions of CNS catecholamines and serotonin (5-HT) have been implicated. In the present paper we summarize evidence to suggest a role for the endogenous opioids in the regulation of normal sleep and in the pathophysiology of the narcoleptic syndrome.Keywords
This publication has 42 references indexed in Scilit:
- Sleep pattern alterations by naloxone. Partial prevention by haloperidolPsychopharmacology, 1984
- Narcolepsy: Cholinergic receptor changes in an animal modelLife Sciences, 1984
- Cerebrospinal fluid monoamine metabolites in narcolepsy and hypersomniaAnnals of Neurology, 1983
- Interactions between serotonergic and enkephalinergic neurons in rat striatum and hypothalamusEuropean Journal of Pharmacology, 1982
- Monoamine metabolite concentrations in the cerebrospinal fluid of normal and narcoleptic dogsBrain Research, 1982
- Effets du refroidissement et de la stimulation des noyaux du systeme du raphe sur les etats de vigilance chez le chatElectroencephalography and Clinical Neurophysiology, 1979
- Naloxone alters pain perception and somatosensory evoked potentials in normal subjectsNature, 1977
- Norepinephrine-Containing Neurons: Changes in Spontaneous Discharge Patterns during Sleeping and WakingScience, 1973
- Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.Journal of Neurophysiology, 1969
- Sleep Deprivation and Brain AcetylcholineScience, 1966