Inactivation Rates of Some Lyophilized Poultry Viruses at 37 and 3°C

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Abstract
Four poultry respiratory disease viruses[long dash] Newcastle disease virus (NDV), infectious bronchitis virus (IBV), laryn-gotracheitis (LTV), and fowl pox virus[long dash]were lyophilized, and rate of inactivation was determined during storage at 37*C. Control tubes were stored at 3*C. The most stable virus in these studies was LTV, followed in order by pox, NDV, and IBV. In general, lyophilized NDV was inactivated within 10 months at 37[degree]C, with some differences noted between two strains and storage conditions. IBV was inactivated at approximately 6 months, with variations between two strains and suspending media. LTV was very resistant to storage at 37[degree]C, and after 3 years the average log titer was 3.8, compared to 5.7 for the control at 3[degree]C. Fowl pox virus was likewise rather resistant, and after 2 years the log titer was 3.0, compared to 5.3 for the controls kept at 3*C.