THE DURATION OF PASSIVE TETANUS IMMUNITY

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Abstract
In the treatment and prophylaxis of tetanus there are several questions of considerable clinical importance for which there are insufficient data to warrant definite answers. Among these may be mentioned: What is the duration of antitoxic immunity after the usual therapeutic dose of tetanus antitoxin? Does any stimulation of antitoxin accompany an attack of clinical tetanus? Can an active antitoxic immunity against tetanus be produced by repeated subcutaneous or intracutaneous injections of toxoid with sufficient rapidity so that such a method could be used as a prophylaxis for wounds? Does the presence of heterologous antitoxin from passive immunization interfere with active immunization against tetanus by toxoid? Has Ramon's "simultaneous serovaccination" against tetanus any merit? In this paper we wish to report observations on the immunization of children with clinical tetanus and of normal children which give information on these questions. MATERIAL AND METHODS The observations

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