The Incidence of H Deficient A2 and A2B Bloods and Family Studies on the AH/ABH Status of an Aint, and Some New Variant Blood Types (Aint H↓A1, A2↑HwA1, A.2↑BHA1B and A2↓BHA2B

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Abstract
The incidence of H deficient A2 blood samples in the Sheffield area was found to be 1 in 169 and 1 in 13 of group A2 and A2B blood samples respectively. Family studies are described on an Aint and on examples of the new variant phenotypes, AintH↓., A2↑HW, A2↑BHW and A2BHW. The sera of some of the variants contained cold anti‐Hs/HIs/HIc/LebH antibodies, but none contained the Bombay type of anti‐Hs active at 37°C. The authors suggest that the modified A status of most of the variants is due to reduced expression of the A1 genes as a result of insufficient production of H precursor substance by weak H alleles. In paternity testing, it is important that an exclusion should not be based on the occurrence of an A1 child of a not A1 group A mating until the A2/A2B parent(s) have been shown to have a normal H status.