Beta Adrenergic Mechanisms Influencing Brain Steady Potential In Cats and Rhesus Monkeys

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Abstract
Beta adrenergic catecholamines and CO2 produce large steady potential (SP) shifts in the brains of both cats and monkeys. Shifts caused by CO2 are blocked at the peak of an adrenergic response. The beta-aminergic shift is rapidly reversed by propranol. These SP shifts are unrelated to changes in cerebral blood flow, brain impedance, or depth of anesthesia. Evidence points to effects on active transport across capillary endothelium or glia adjacent to the vascular lumen. Paired microelectrodes which straddle the blood brain barrier (BBB), even when placed within 1 millimeter of each other to record between sagittal sinus and subarachnoid space, give results identical with those obtained by less direct methods. These potential shifts across the barrier are sufficiently different from most previously described SP phenomena to be distinguished from them; the term ‘intracranial transvascular potential (ITVP)’ shift is proposed to describe them.

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