EFFECTS OF A POLYCHLORINATED BIPHENYL (PCB) ON SLEEPING TIMES, PLASMA CORTICOSTEROIDS, AND TESTICULAR ACTIVITY OF WHITE-FOOTED MICE

  • 1 January 1975
    • journal article
    • research article
    • Vol. 5  (5) , 308-313
Abstract
Forty adult male white-footed mice (Peromyscus leucopus) were divided into four equal groups and fed diets containing 0, 100, 200 or 400 p.p.m. of a polychlorinated biphenyl (PCB) for 2 weeks. PCB ingestion increased liver weights and reduced pentobarbital-induced sleeping times at all levels tested, indicating increased hepatic microsomal enzyme activity. Plasma corticoid levels, seminal vesicle weights and testicular spermatozoa numbers were reduced at the 400 p.p.m. level.

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