Influence of Low Protein Diet on Distribution of D-Amino Acid Oxidases in Rats.

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Abstract
In connection with expts. on the influence of nutrition on the development of hepatic tumors, the effect of nutritional factors on the amino acid oxidases was studied. Wistar rats were divided into 3 groups: a) on low protein diet, b) low protein diet with the addition of alpha estradiol (5 gamma daily), c) on a full diet. The D-amino acid oxidase was detd. by measuring tne O2 uptake of liver or kidney homogenates in the presence of D-L-alanine or D-aspartic acid as substrate by the Warburg technique. In the livers of both groups of rats on low protein diet, the amino acid oxidase levels dropped to half of that of rats on a full diet. The levels in the kidneys were the same in all 3 groups. In view of the role of the liver in protein metabolism, the finding that on reduction of dietary proteins a decrease of the amino acid oxidase occurred in livers only, might be of physiological importance.

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