Breast Carcinoma with Positive Results for Melanoma Marker (HMB-45): HMB-45 Immunoreactivity in Normal and Neoplastic Breast

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Abstract
HMB-45 (melanocyte cell-specific monoclonal antibody) immunoreactivity has been detected by the immunoperoxidase technique in the cytoplasm of 2 of 100 breast carcinomas. In addition, normal breast lobules and ducts were occasionally found to have positive results in 6 of 100 cases. These findings indicate the need to exercise caution in the interpretation of HMB-45 immunoreactivity for immunohistochemical characterization of neoplasms.