The Nafion-H-catalyzed Acylation of Thiophene with Acid Anhydrides

Abstract
The reaction of thiophene with acyclic acid anhydrides in the presence of Nafion-H (fluorocarbon resin sulfonic acid) afforded the corresponding 2-acylthiophenes in moderate yields. Acylation with cyclic acid anhydrides gave only low yields, however. The Nafion-H catalyst could be reused for the acylation with a little loss of activity.