Prolongation of life span of dystrophic hamster by cysteine proteinase inhibitor, loxistatin (EST).
- 1 January 1987
- journal article
- research article
- Published by Pharmaceutical Society of Japan in Journal of Pharmacobio-Dynamics
- Vol. 10 (11) , 678-681
- https://doi.org/10.1248/bpb1978.10.678
Abstract
We studied the effect of loxistation (EST), an orally applicable cysteine proteinase inhibitor, on dystrophic hamsters, UM-X7.1.E-64-c, an active form of EST, was continuously found in plasma when the feed containing EST was given ad libitum. The drug concentration in plasma of dystrophic hamsters receiving EST feed showed distinct dose dependency. A diet containing EST from weaning to death significantly prolonged the survival period of the dystrophic hamsters.This publication has 3 references indexed in Scilit:
- Limited benefit to genetically dystrophic chickens from a synthetic proteinase inhibitor: Ep475Journal of the Neurological Sciences, 1983
- Reaction of Calcium-Activated Neutral Protease (CANP) with an Epoxysuccinyl Derivative (E64c) and Iodoacetic Acid1The Journal of Biochemistry, 1983
- Ca‐activated neutral protease and its inhibitors: In vitro effect on intact myofibrilsMuscle & Nerve, 1980