Debrisoquine oxidation phenotype and susceptibility to lung cancer.
Open Access
- 1 January 1990
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 29 (1) , 101-109
- https://doi.org/10.1111/j.1365-2125.1990.tb03608.x
Abstract
1. It has been suggested that poor metabolisers of debrisoquine are at reduced risk of developing lung cancer from smoking cigarettes. This has been investigated in 82 patients with established cancer of the lung. 2. The frequency of poor metaboliser subjects was not different from that in the normal population. 3. There was no tendency for subjects with lung cancer to metabolise debrisoquine more rapidly than non-cancer subjects. 4. It is concluded that debrisoquine metabolic phenotype is not a good predictor of risk of developing lung cancer in the population at large.This publication has 22 references indexed in Scilit:
- Characterization of the common genetic defect in humans deficient in debrisoquine metabolismNature, 1988
- P450 GENES: STRUCTURE, EVOLUTION, AND REGULATIONAnnual Review of Biochemistry, 1987
- Polymorphic drug oxidation: pharmacokinetic basis and comparison of experimental indices.British Journal of Clinical Pharmacology, 1986
- Metabolic oxidation phenotypes as markers for susceptibility to lung cancerNature, 1984
- The genetic control of sparteine and debrisoquine metabolism in man with new methods of analysing bimodal distributions.Journal of Medical Genetics, 1983
- The electron capture negative ion chemical ionization mass spectra of 2-(4′,6′-bistrifluoromethyl-2′-pyrimidinyl)-tetrahydroisoquinoline and 4-substituted analoguesJournal of Mass Spectrometry, 1982
- Chemical CarcinogenesisNew England Journal of Medicine, 1981
- A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.Journal of Medical Genetics, 1980
- POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MANThe Lancet, 1977
- Determination of debrisoquin and its 4-hydroxy metabolite in plasma by gas chromatography/mass spectrometryAnalytical Chemistry, 1976